First report of pembrolizumab extravasation

Pembrolizumab: First in Class for Treatment of Metastatic Melanoma

Author's disclosures of potential conflicts of interest are found at the end of this article. M alignant melanoma accounts for only 2% of skin cancers, but it is the most deadly form of skin cancer. Melanoma rates have been increasing over the past 30 years. Melanoma is 10 to 20 times more common in Caucasians than in those of Hispanic or African descent. Metastatic (or stage IV) melanoma has a...

Pembrolizumab

The development of the cytotoxic T-lymphocyte-associated protein 4 inhibitor ipilimumab and its approval in 2011 for the treatment of metastatic melanoma has heralded a new era in immuno-oncology. Subsequently, novel agents against the programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1) axis have shown significant activity in melanoma and a variety of other tumor types...

First report of Chromelosporium fulvum from Iran

During spring 2011, some fungal isolates were recovered from sterilized soil (Fig. 1, A) or vermiculite, in pots and flats in greenhouses in Shiraz University, using malt extract agar and potato dextrose agar (Fig. 1, B). Anamorphic characteristics such as conidiophores and conidia were investigated. Conidiophores 125–1350 × 7.5–15 µm, hyaline, erect, broad, septate, branched once, twice (Fig. ...

First report of Strobilomyces strobilaceous from Iran

In the framework of collection and identification of bolete fungi of Iran, one specimen from the genus Strobilomyces was collected and identified as Strobilomyces strobilaceus (Scop.) Berk., based on Knudsen & Vesterholt (2008).

First report of Coprinopsis urticicola from Iran